You won't be able to disconnect one fuel line and hope to pump out the fuel. The fuel pump will run while the engine is cranking and for 1.5 seconds after it stops. To crank the engine for the length of time it would take to pump the majority of gas out of a full tank could be damaging to the starter motor (potential starter overheat, and battery overheat). The tank is heavy but not unwieldy.
If your objective is strictly to remove a full tank to access under the tank, the process is straightforward. The tank does become heavy but it's not unmanageable, even by one person alone. I've done this many times myself. If you fully disconnect the fuel lines and electrical connector, no fuel will leak out of the tank and it can be moved without worry of spillage, so long as it is kept upright.
If your objective is to work inside the tank, what I suggested earlier is also manageable, even by one person. Being careful is absolutely paramount because of the open fuel, risk of spillage and potential fire hazard.
EDIT: Just throwing an idea out there. You might be able to rig an external battery to drive the fuel pump through the tank connector, if you can find a reliable means to connect the two leads (+ve and -ve) to the connector. Then disconnect the fuel line at the fuel rail, direct it into a pail and run the pump from the external battery source. The danger with this is the risk of fire due to sparking arising from trying to connect the battery to the connector. Those sparks in the vicinity of fuel vapours is a fire hazard.