I doubt that I will ever open the throttle wide enough yo get the engine to knock. At the throttle opening I normally run at, the cylinder pressure doesn't get anywhere near the ping range.
Having said that, I have seen enough problems with ethanol in the boat business to want to avoid that crap in my bikes every chance I get. Fortunately, there are two stations selling no corn, one near home and the other close to where I work so it's easy to indulge myself. I figure it cost me about an extra $40 a year to run real gasoline in my babies. When I am on trips, I don't worry so much about putting moonshine in my bike because it's only in there for a couple of hours before it's burned up. As soon as I get home though, it's back to the real stuff.