... replaced the rear pads on my K1100LT and adjusted the set screw and locknut on the pedal so that the pads would start to bite with minimal downward movement of the pedal...
Laitch and Martin already addressed free-play, new parts will remove free-gaps between them after reassembly. Tightening the adjusters to "bite" with minimal pedal movement was your undoing. Due to wear and corrosion the tolerance stack-up between parts can change after reassembly.
This just happened to me on a 36 year old 1981 R100RS. I thoroughly cleaned the front brake system including the master cylinder and the front brake seemed normal, but on a test ride it bound-up on the San Diego 405 freeway. Dismantled the master cylinder again to find the MC piston was covering the single supply and return passages in the master cylinder. Taken a step further, here's a photo of the front brake master cylinder showing the supply and return holes. On this particular cylinder the supply hole (left) is clear, the return hole(right) was never drilled through. Yes that is correct, perhaps a quality problem. The blocked passage only arose because I took the cylinder apart to clean it, when reassembled the parts fit tighter (looser?) covering the supply passage. At freeway speed with a hot motor cooking the brake lines and hot brakes the brake pressure elevated, with nowhere for the pressure to go the brakes applied.
My K75 has a similar Magura master cylinder with a supply and return hole, the return hole appears to have a ceramic or fibrous filter covering it. So far despite my cleaning that brake system, the blockage didn't occur and no brake lock-up.
If there is a BMW service manager reading this maybe he/she can explain the missing return hole on the R100RS brake master cylinder for that model and year 1981. If any other "R" owners out there have experienced this problem please share your story.