20,000 km is the figure I've read regarding the frequency. It's not unusual to see the dryness of the splines after the Honda moly application. The soap-based carrier in Honda Moly60 will be quickly flung off in use, around the final drive housing and inside the drive shaft, in a very short time. The active ingredient, the Molybdenum Sulphide, imbeds into the steel and continues to work. Anything you can do to prevent the carrier from disappearing rapidly will add time to the process of absorbing the moly. Therefore, Guard Dog has a thicker carrier that inhibits this. Similarly, mixing your favourite moly paste with a very high viscosity carrier like Wurth SIG 3000 Spline Grease will accomplish the same thing. That's what I do -- use a 50/50 mix of Honda and Wurth products. The stuff is like melted Mozzarella cheese, all stringy and gluey. And it sticks to anything so handling it cleanly is challenging, but it works great.
Honda Moly60 is no longer in production and its substitute is Honda M-77 assembly lube.