IMO such a performance differential between cylinders has to be explained in the ignition chain for individual cylinders, I.e. throttle bodies, valves or coils and you should be checking the things first that could cause the most damage if left unattended. So -- in short, valve clearance.
Everything I've read on the subject says you should always do a valve clearance check _before_ the leak down test because if a valve isn't seated properly it will result in leak down, ergo the test won't tell you anything about the engine except that you may have valve clearance issues. You have to isolate variables. Do the the valve adjustment first and you know the valves are good, so the leakdown values pertain to the actual engine i.e. cylinder performance.
Valve clearance out of spec doesn't mean the cylinder isn't firing. It is. So you may not perceive that the engine is running poorly. What will happen, though, is that the valve will eventually burn up leaving you with a non-running brick and few options that don't cost ch1tloads of money.
So even though your poor fuel consumption may have other causes, maybe at this point you should be more concerned about #3 valve. Bad fuel consumption sucks, engine damage sucks a$$.
My $0.02...